Open Access Research

Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis

Filipe Santos1,2,6†, Jennifer K Spinler3,4†, Delphine MA Saulnier3,4,7†, Douwe Molenaar1,2, Bas Teusink1,2, Willem M de Vos5, James Versalovic3,4 and Jeroen Hugenholtz2,6*

1 Center for Integrative Bioinformatics, Vrije Universiteit Amsterdam, Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

2 TI Food and Nutrition, Kluyver Centre for Genomics of Industrial Fermentation, and NCSB, Nieuwe Kanaal 9A, 6709 PA, Wageningen, The Netherlands

3 Department of Pathology & Immunology, 1 Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA

4 Department of Pathology, Texas Children's Hospital, 1102 Bates Avenue, Houston, TX 77030, USA

5 Laboratory of Microbiology, Wageningen University and Research Centre, Dreijenplein 10, 6703 HB Wageningen, The Netherlands

6 Department of Microbiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands

7 Current Address: NIZO Food Research, Ede, 6710 BA, the Netherlands

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Microbial Cell Factories 2011, 10:55 doi:10.1186/1475-2859-10-55

Published: 21 July 2011

Additional files

Additional file 1:

Transcriptome analysis data. Single PDF containing three tables with additional transcriptome analysis data: Additional file 1, Table S1, Complete list of transcripts from L. reuteri that are differentially expressed by the overexpression of lreu_1750; Additional file 1, Table S2, Distribution of transcripts listed in Additional file 1, Table S1 throughout categories of clusters of orthologuous groups (COG, [35]); Additional file 1, Table S3, Complete list of loci from L. reuteri ATCC PTA 6475 that are differentially expressed by the disruption of the putative PocR.

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Open Data