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Open Access Review

Comparative modelling of protein structure and its impact on microbial cell factories

Nuria B Centeno, Joan Planas-Iglesias and Baldomero Oliva*

Author Affiliations

Structural Bioinformatics Laboratory, Research Group on Biomedical Informatics (GRIB), IMIM/UPF. c/ Dr. Aiguader 80. 08003 Barcelona, Spain

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Microbial Cell Factories 2005, 4:20  doi:10.1186/1475-2859-4-20

Published: 30 June 2005

Abstract

Comparative modeling is becoming an increasingly helpful technique in microbial cell factories as the knowledge of the three-dimensional structure of a protein would be an invaluable aid to solve problems on protein production. For this reason, an introduction to comparative modeling is presented, with special emphasis on the basic concepts, opportunities and challenges of protein structure prediction. This review is intended to serve as a guide for the biologist who has no special expertise and who is not involved in the determination of protein structure. Selected applications of comparative modeling in microbial cell factories are outlined, and the role of microbial cell factories in the structural genomics initiative is discussed.