Microbial Cell Factories
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  ReviewEnsuring safety of DNA vaccinesJacob Glenting1  and Stephen Wessels2  1
Bioneer A/S, DK-2970 Hørsholm, Denmark 2
Danish Toxicology Centre, DK-2970 Hørsholm, Denmark  author email corresponding author email
Microbial Cell Factories 2005,
4:26doi:10.1186/1475-2859-4-26
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| Published: |
6 September 2005 |
Abstract
In 1990 a new approach for vaccination was invented involving injection of plasmid DNA in vivo, which elicits an immune response to the encoded protein. DNA vaccination can overcome most disadvantages of conventional vaccine strategies and has potential for vaccines of the future. However, today 15 years on, a commercial product still has not reached the market. One possible explanation could be the technique's failure to induce an efficient immune response in humans, but safety may also be a fundamental issue. This review focuses on the safety of the genetic elements of DNA vaccines and on the safety of the microbial host for the production of plasmid DNA. We also propose candidates for the vaccine's genetic elements and for its microbial production host that can heighten the vaccine's safety and facilitate its entry to the market. | 
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