Microbial Cell Factories
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 ReviewInteins and affinity resin substitutes for protein purification and scale upMahmoud Reza Banki  and David W Wood  Department of Chemical Engineering, A213 E-QUAD, Princeton University, Princeton, NJ 08544, USA  author email corresponding author email
Microbial Cell Factories 2005,
4:32doi:10.1186/1475-2859-4-32
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| Published: |
11 November 2005 |
Abstract
The development of self-cleaving fusion-tag technology has greatly simplified the purification of recombinant proteins at laboratory scale. The self-cleaving capability of these tags has recently been combined with additional purification tags to generate novel and convenient protein purification methods at a variety of scales. In this review, we describe some of these methods, and provide a rudimentary economic analysis of hypothetical large-scale applications. This work is expected to provide a rough outline for the evaluation of these methods for large-scale bioprocessing of a variety of products. | 
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