|
Attenuated bacteria as vaccine vehicles |
||||
| Vaccine strain |
Attenuation |
Foreign insert |
Model |
Ref. |
|
|
||||
| Shigella flexneri |
Δasd |
pCMVβ |
Guinea pig, in vitro |
[80] |
| Δasd |
CS3 and LTB/STm |
Mouse |
[81] |
|
| ΔrfbF |
HIV-1 SF2Gag |
Mouse |
[17] |
|
| ΔdapA ΔdapB |
β-gal, gene vaccine |
In vitro |
[16] |
|
| ΔaroA ΔiscA |
gp120, gene vaccine |
Mouse |
[15] |
|
|
|
||||
| Salmonella enterica |
ΔaroA |
pCMVβ, pCMVactA and pCMVhly |
In vitro, mouse |
[82] |
| ΔaroA ΔaroD |
C. tetani TTFC |
Mouse |
[83] |
|
| ΔaroA ΔhtrA |
TTFC |
Mouse |
[83] |
|
| ΔaroA+others |
GFP+cytokines |
Mouse |
[84] |
|
| Δcya Δcrp Δasd |
SP10 cDNA |
Mouse |
[20] |
|
| GalE + unspecified |
H. pylori, ureAB |
Human |
[85] |
|
|
|
||||
| Yersinia enterocolitica |
pYV- |
B. abortus, P39 |
Mouse |
[86] |
| pYV- |
Ova |
Mouse |
[87] |
|
|
|
||||
| Listeria monocytogenes |
ΔactA |
Leichmania major |
Mouse |
[88] |
| ΔactA |
LCM virus |
Mouse |
[89] |
|
| Δdal Δdat |
HIV-1 gag gene vaccine |
Mouse |
[90] |
|
| Δ2 |
M. bovis gene vaccine |
Mouse |
[91] |
|
|
|
||||
| Bordetella bronhiseptica |
ΔaroA |
TTFC |
Mouse |
[92] |
|
|
||||
| Erysipelotrix rhusiopatie |
Tn916- |
M. hyopneumonie |
Mouse, pig |
[93] |
|
|
||||
| Mycobacterium bovis |
unspecified |
P. falciparum, CSP |
Mouse |
[94] |
|
|
||||
| Brucella abortus |
Rough mutant (O-) |
lacZ or HSP65 |
Mouse |
[95] |