Figure 6.

Metabolic pathway for GDP-fucose synthesis using natural GDP-fucose synthesis pathway [15]. Enzymes – 1: phosphomannose isomerase (ManA), 2: phosphomannomutase (ManB), 3: mannose-1-phosphate guanylyltransferase (ManC), 4: GDP-mannose-4,6-dehydratase and GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase (Gmd, WcaG), 5: putative UDP-glucose lipid carrier transferase (WcaJ).