Saccharomyces cerevisiae: a versatile eukaryotic system in virology

doi:10.1186/1475-2859-6-32

Microbial Cell Factories
Volume 6

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Galao RP
Scheller N
Alves-Rodrigues I
Breinig T
Meyerhans A
Díez J

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Scheller N
Alves-Rodrigues I
Breinig T
Meyerhans A
Díez J
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Review

Saccharomyces cerevisiae: a versatile eukaryotic system in virology

Rui P Galao¹ , Nicoletta Scheller¹^,2 , Isabel Alves-Rodrigues¹ , Tanja Breinig² , Andreas Meyerhans² and Juana Díez¹^,2

¹Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain

²Institute of Virology, Saarland University, 66421 Homburg, Germany

author email corresponding author email

Microbial Cell Factories 2007, 6:32doi:10.1186/1475-2859-6-32


Published:	10 October 2007

Abstract

The yeast Saccharomyces cerevisiae is a well-established model system for understanding fundamental cellular processes relevant to higher eukaryotic organisms. Less known is its value for virus research, an area in which Saccharomyces cerevisiae has proven to be very fruitful as well. The present review will discuss the main achievements of yeast-based studies in basic and applied virus research. These include the analysis of the function of individual proteins from important pathogenic viruses, the elucidation of key processes in viral replication through the development of systems that allow the replication of higher eukayotic viruses in yeast, and the use of yeast in antiviral drug development and vaccine production.