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Open Access Highly Accessed Editorial

Recombinant protein production in the new Millennium

Antonio Villaverde123 and Diethard Mattanovich45*

Author Affiliations

1 Institute for Biotechnology and Biomedicine, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain

2 Department of Genetics and Microbiology, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain

3 CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Bellaterra, 08193 Barcelona, Spain

4 University of Natural Resources and Applied Life Sciences Vienna, Department of Biotechnology, Institute of Applied Microbiology, Vienna, Austria

5 School of Bioengineering, University of Applied Sciences FH-Campus Vienna, Austria

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Microbial Cell Factories 2007, 6:33  doi:10.1186/1475-2859-6-33

Published: 20 October 2007

First paragraph (this article has no abstract)

In 2000, the Microbial Physiology Section of the European Federation of Biotechnology gathered the academic and industrial community involved in the production of heterologous proteins for an update on physiological aspects governing protein production in prokaryotic and eukaryotic cells. While there was common understanding that the limits of efficiency in productivity and quality had by far not been reached, that meeting concentrated on a comparative description of physiological events, from genetic stability via transcription and translation to protein folding and secretion [1]. Despite the progressive comprehension of physiological limitations and cellular stresses in producing cells, there were only few examples of cell engineering towards improved expression systems.